Antigen

Tumor

Immunization schedule

Adjuvant

Antitumor activity

Comments

Reference

b-gal

adeno carcinoma

DNA gene gun bombardment followed by cytokine i.p.

Cytokines

(IL-2, IL-12)

treatment of 2-day-old pulmonary metastases

-

[Irvine et al., 1996]

gag from M-MuLV

   leukemia

DNA i.m., 3 inoculations every 10 days

none

complete protection from challenge

-

[Milan et al., 1999]

HPV-E7

sarcoma

DNA 3 gene gun bombardments, every 2 weeks

none

complete protection from challenge

-

[Tuting et al., 1999]

b-gal

adeno carcinoma

VV single i.v. injection

IL-2, IL-12, B7-1

treatment of 3 to 6-day-old pulmonary metastases

cytokines and costimulatory molecules were given exogenously or produced by the same VV encoding the model antigen

[Bronte et al., 1995; Carrol et al., 1998; Chamberlain et al., 1996; Rao et al., 1996]

b-gal

adeno carcinoma

MVA single i.v. injection

none

treatment of 3-day-old pulmonary metastases

MVA was superior to a VV-based vaccine

[Carrol et al., 1997]

b-gal

adeno carcinoma

S. thyphimurium given orally at 15 day-intervals

none

partial protection from challenge

surviving mice rejected a second challenge

[Paglia et al., 1998]

NP

Adeno carcinoma, renal cell carcinoma

L. monocytogenes given orally at different intervals

none

protection from challenge; growth retardation of established subcutaneous tumors

therapeutic effect dependent on the tumor type

[Pan et al., 1995]

NP

melanoma

L. monocytogenes given orally at weekly intervals

VV-NP;

GM-CSF secreting tumor cell vaccine

partial therapy of 4-5 mm tumors

therapy was not improved by joint administration of other vaccines

[Pan et al., 1999]

b-gal

adeno carcinoma

self-replicating RNA

none or IL-12

treatment of 2-day-old pulmonary metastases

IL-12  improved the survival

[Ying et al., 1999]

b-gal

adeno carcinoma

first generation adenovirus, single i.v. inoculation

IL-2

treatment of 3-day-old pulmonary metastases

high virus titer and IL-2 required for therapy

[Chen et al., 1996]

b-gal

adeno carcinoma

FPV, single i.v. inoculation

none

treatment of 3-day-old pulmonary metastases

limited survival  prolongation-

[Wang et al., 1995a]