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Current Medicinal Chemistry -

Anti-Cancer Agents

  

Contents

 

Preface   DNA Topoisomerases as Anticancer Drug Targets: From the Laboratory to the Clinic Joseph A. Holden

Novel Cyclopropylindole Conjugates and Dimers: Synthesis and Anti-Cancer Evaluation Sanjay K. Sharma, Guofeng Jia and J. William Lown

Prostate Cancer: Horizons in the Development of Novel Anti-Cancer Strategies A.G. Papatsoris and A.G. Papavassiliou

Peptides as Carrier for Tumor Diagnosis and Treatment M. Langer and A. G. Beck-Sickinger

A New Concept for the Design of Antisense Oligonucleotides Based on Nucleic Acid Thermostability Naoki Sugimoto and Isao Yasumatsu

 

This is to acknowledge that the slide shown on the front cover of this journal was kindly supplied by Prof. Michelle Prudhomme, UMR 6504, U.F.R. de Recherche Scientifique et Technique, Universite Blaise Pascal - C.N.R.S., 24, Avenue des Landais, 63177 Aubiere Cedex, France. The figure shows the minor groove of an energy-minimized model of the complex between an antitumor rebeccamycin analog and the hexanucleotide d(CGCGCG)₂. The molecular model illustrates the interaction of the planar indolocarbazole chromophore and the location of the carbohydrate in the minor groove of the double helix.