(Table 2). contd….

No.	HeLa S3 IC50 (nM)^a	Sarcoma 180 (sc-iv)^b	Hematotoxicity
	1 h 72 h	Dose (mg/kg) T/C^c	WBC^d (%) PL^e (%)
64	59 3.2	4.0 0.19	22 94
65	0.64 0.082	0.5 0.22	29 87
66	4.2 0.27	2.0 0.07	26 91
58	0.045 0.0052	0.25 0.21	22 38
57	53 1.6	0.63 0.15	24 10

^a Drug concentration required to inhibit the growth of HeLa S3 cells by 50%.

^b Mice (five mice/group) were implanted subcutaneously (sc) with tumor cells, and the drug was dosed (mg/kg) intravenously (iv).

^c T and C are the values of mean tumor volume of treated and control mice respectively.

^d Number of white blood cells of tumor-bearing mice on day 4 (% of control).

^e Number of peripheral platelets of normal mice on day 7 (% of control).