Contents

Preface

An Approach to the Rational Design of Opioid Receptor Ligands : Non-narcotic k-Opioid Receptor Ligand KT-95 Free from Euphoria and/or Dysphoria

Ken Kanematsu and Takeshi Sagara

Metabotropic GABAB Receptors: New Challenges in Drug Design

D.I.B. Kerr and J. Ong

Conformationally Constrained Butyrophenones. Synthesis and Evaluation as Antipsychotics

Enrique Raviña and Christian F. Masaguer

The CRF Receptor: Structure, Function and Potential for Therapeutic Intervention

Dimitri E. Grigoriadis, Mustapha Haddach, Nick Ling and

John Saunders

Integrating Virtual Screening Methods to the Quest for Novel Membrane Protein Ligands

Gisbert Schneider, Werner Neidhart and Geo Adam