Table 3.        Inhibitory Effects (pIC50 values) of KT-95, KT-90 and Morphine on the specific Binding of 3H-Labeled Opioid Ligands to Rat Brain Crude Synaptosomal Fractions

 

m-sites
[3H]naloxone

d-sites
[3H]DADLE

k-sites
[3H]U-69593

KT-95

8.59±0.01 (3)

8.56±0.15 (3)

9.62±0.21 (3)

KT-90

8.99±0.22 (4)

8.54±0.17 (4)

8.93±0.11 (3)

morphine

8.45±0.15 (3)

7.20±0.12 (3)

8.37±0.17 (4)

Each value represents the mean ±S.E.

The number of experiments is indicated in parentheses.