Current Organic Chemistry

ISSN: 1385-2728

Current Organic Chemistry
Volume 11, Number 10, July 2007

Contents

Heterocyclic Chemistry
Guest Editor: Jan Bergman


Editorial Pp. 845


Chemical and Pharmacological Significance of 1,4 Dihydropyridines Pp. 847-852
Ghanta Mahesh Reddy, Mehendra Shiradkar and Akula Kalyan Chakravarthy
[Abstract]


Utilities of Some Carbon Nucleophiles in Heterocyclic Synthesis Pp. 853-908
H. M. F. Madkour and A. S. H. Elgazwy
[Abstract]


General Articles


Current Mass Spectrometry of Synthetic Polymer Pp. 909-923
Meiyu He and Hui Chen
[Abstract]


The Prins Reaction: Advances and Applications Pp. 925-957
Isidro M. Pastor and Miguel Yus
[Abstract]




Abstracts

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Editorial

1,4-Dihydropyridines are of great chemical and pharmacological significance as evidenced from a chapter written by Drs Reddy and Chakravarty form Dr Reddy’s Laboratories Ltd, Hyderabad, India.

It is well-known that carbon nucleophiles are useful in organic synthesis in general and in heterocyclic synthesis in particular. In the final comprehensive chapter Professors Madkour and Elgazwy from Ain Shams University, Cairo, Egypt discusses new developments in this field.


Jan Bergman
KI, Dept. of Biosciences at Novum
Unit of Organic Chemistry
SE-141 57 Huddinge
Sweden


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Chemical and Pharmacological Significance of 1,4 Dihydropyridines
Ghanta Mahesh Reddy, Mehendra Shiradkar and Akula Kalyan Chakravarthy

1,4-Dihydropyridines are excellent precursors of various pharmacologically important molecules which possess calcium channel blocking activity. The synthesis of various 1,4-dihydro pyridines and their importance is reviewed for the first time to our knowledge.


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Utilities of Some Carbon Nucleophiles in Heterocyclic Synthesis
H. M. F. Madkour and A. S. H. Elgazwy

New developments in the utilities of some carbon nucleophiles in heterocyclic synthesis are reviewed. General synthetic routes based on the utilization of carbon nucleophiles of active methylene are discussed. The major methods and modifications are analyzed. Heterocycles are ubiquitous in all kind of compounds of interest, and among all the possible synthetic methods of achieving their introduction into a structure, probably the use of a carbon nucleophile analogues are the most direct one. The present review deals with the generation and synthetic of carbon nucleophile, which uses as scaf-fold for the heterocyclic synthesis, and can be considered as an update review. Therefore the only references published upon the second quarter of 2003 are included, and the same restrictions to the literature coverage apply.


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Current Mass Spectrometry of Synthetic Polymer
Meiyu He and Hui Chen

As the well-known soft ionization techniques, matrix assisted laser desorption/ionization (MALDI) – time of flight (TOF) mass spectrometry and electrospray ionization (ESI) MS are widely used in the investigative field of macromolecules including biomolecules and synthetic polymers since they were introduced in the late 1980s. Herein, emphasis is put on the application of MALDI-TOF MS and ESI MS on synthetic polymers by reviewing the literature in recent two decades. The applications to the characterization of synthetic polymers covering determination of molecular weight, structure analysis and quantitation by MALDI-TOF are reviewed. The combination with other analytic methods such as size exclusion chromatography (SEC) opened a new gate for the characterization of broad polydispersed polymers. The applications on different classes of synthetic polymers indicate that MALDI-TOF MS is ideal tools for the characterization of synthetic polymers.


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The Prins Reaction: Advances and Applications
Isidro M. Pastor and Miguel Yus

The acid-catalyzed alkene-aldehyde condensation, known as the Prins reaction, is reviewed. Lewis acids, organic acids and supported catalysts have been reported to assist both the Prins acyclic reaction and the Prins cyclization. Acetals and oxocarbenium ions (generated from aldehydes and alcohols) have been described as reacting systems in the Prins reaction. Prins cyclizations have been used to form mainly five- and six-membered rings, albeit formation of seven to nine rings have been described. The Prins reaction (and cyclization) has been developed as a key strategic element in the total synthesis of different natural products.