Compound	Experimental Model	Dose
Roscovitine	Glomerulonephritis [59]	2.8 mg/kg (daily)
CVT-313	Restenosis (rat carotid artery) [16]	1.25 mg/kg
UCN-01	Epidermoid carcinoma xenograft [52] Fibrosarcoma xenograft [52] Acute myeloid leukemia xenograft [52] Pancreatic tumor xenograft [53] Glioma xenograft [23] Murine fibrosarcoma [52]	5 mg/kg 7 mg/kg 7 mg/kg 9 mg/kg 1-2 mg/kg (daily) 7.5 mg/kg
CGP 41 251	Gastric, colorectal, breast and lung cancer xenografts [54] Murine melanoma [54]	200 mg/kg (daily) 75 mg/kg (three times daily)
Indirubin	Murine sarcoma [25]
Flavopiridol	Head and neck squamous cell carcinoma xenograft [55] Colon carcinoma xenograft [56] Prostate cancer xenograft [57] Leukemia and lymphoma xenograft [58] Restenosis (rat carotid artery) [60] Mouse Matrigel model of angiogenesis [56]	5 mg/kg (daily) 5 mg/kg (every other day) 10 mg/kg (daily) 7.5 mg/kg (daily) 5 mg/kg (daily) 18 mg.kg (daily)

References are in parenthesis

Table 3. Use of CDK Inhibitors in Animal Models of Disease