| Letters
in Drug Design & Discovery
ISSN: 1570-1808
Letters in Drug Design &
Discovery
Volume 3, Number 9, November 2006
| Peptide Hormones: Therapeutic
Targets in Appetite Regulation Pp. 593-597 |
A.M. Wren & S.R. Bloom
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| Glycosyl Phosphatidylinositol-Anchored
Proteins and HIV Infection Pp. 598-604 |
M. Alfano, L. Cassetta &
G. Poli
Glycosyl phosphatidylinositol-anchored proteins
(GPI-APs) have been involved in the regulation of
many pathogens, including the human immunodeficiency
virus (HIV). Understanding how GPI-APs finely regulate
HIV infection and replication may unravel novel
and complementary strategies to combat and control
HIV infection. |
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| Oral Fluid Drug Testing in Social
Science Settings: A Summary Report Pp. 605-606 |
G.S. Yacoubian, Jr
Though urinalysis is recognized as the criterion
measure of recent drug use, oral fluid (OF) testing
has emerged as a viable alternative with greater
serviceability. Despite its emergence, research
gaps remain. This essay summarizes the OF literature
in social science settings and provides recommendations
for future OF drug testing research. |
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| ABC Transporters and Isothiocyanates
Pp. 607-621 |
I.D. Kerr & N.S. Simpkins
Dietary isothiocyanates have a broad spectrum of
effects, including interaction with multi-drug resistance
ABC transporters. Other, more complex, naturally
occurring isothiocyanates such as welwistatin offer
the potential for specific inhibition of these mediators
of cancer drug resistance. |
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| Development of Quantitative Structure-Activity
Relationship for a Set of Carbonic Anhydrase Inhibitors:
Use of Quantum and Chemical Descriptors Pp. 622-635 |
P.V. Khadikar, O. Deeb, A. Jaber,
J. Singh, V.K. Agrawal, S. Singh & M. Lakhwani
A set of 24 descriptors consisting of quantum and
chemical descriptors have been used for modeling
binding constant (logK) of the benzene sulfonamides
to human CAII. The results are critically discussed
using a variety of statistics, which indicated that
the hydrophobic term (logP) is not that essential
to yield an excellent models.
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| Microfluidic Systems for Studying
Cell Migration Regulation Pp. 636 639 |
J.F. Zhong, G. Maltezos, Z.
Sheriff, K. Burke, A. Scherer, C.R. Taylor &
W.F. Anderson
Nanofabricated microfluidic systems were constructed
to study the chemical gradient independent migration
behaviors of two cell lines in vitro. These
microfluidic systems can be a powerful means to
study cell disassociation, which is the first step
of cancer metastasis. |
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| Cytotoxicity of Native Sponges
and Plants from the Colombian Caribbean Coast Against
“Crown Gall” Tumors Induced by Agrobacterium
tumefaciens Pp. 640-644 |
F. Díaz, R. Gaitán,
D. Urbina, K. Mendoza, M. Puello, G. Torres &
E. de Avila
The cytotoxicity activity of extracts from Tabebuia
and Xetospongia spp. was evaluated using
crown-gall-like tumors in the potato discs induced
by Agrobacterium tumefaciens. Dichloromethane
and methanol soluble extracts of Xetospongias
spp. showed the highest biological activity. |
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| Comparison of Noradrenergic Receptor
Distribution in the Hippocampus of Rodents and Humans:
Implications for Differential Drug Response Pp.
645-652 |
P. Szot
This review examines the differences in the localization
of the noradrenergic receptors in the hippocampus
of humans and rodents. The differences in receptor
localization could have major implications for the
actions (side effects) of noradrenergic agents in
humans. |
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| Is Beta-Blocker Treatment Associated
with a Decrease in the Risk of Cancer Pp. 653-661 |
M. Algazi, G. Plu-Bureau, A.
Flahault, M-G Dondon & M.G. Lê
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| Differential Modulation Of TNfα-Induced
Cell Death By 3-Methyladenine, An Autophagy Inhibitor
Pp. 662-667 |
P. Costelli, D. De Stefanis,
P. Reffo, R. Autelli, G. Bonelli & F.M. Baccino
The present study investigates if TNFα-induced
death in cell types of different origin can be modulated
by interference with the autophagic process. All
the cell lines tested undergo apoptosis or apoptosis-like
death in response to TNFα.
However, when the cytokine is coupled with 3-methyladenine,
a well known inhibitor of the autophagic process,
HTC cells are partially protected from TNFα-induced
death, whereas HT-29, L929 and U937 cells are sensitized,
albeit to varying degrees. These results show that
3 methyladenine can modulate TNFα-induced
death both positively and negatively, depending
on the cell type. |
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| Eicosanoids as Therapeutic Targets
in Asthma Pp. 668-674 |
P. Rastogi & J. McHowat
Arachidonic acid metabolites play a major role in
pathophysiology of asthma. Current strategies used
to target these metabolites are examined. Inhibition
of phospholipases which release arachidonic acid
from membrane phospholipids may provide yet another
avenue to target this disease. |
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